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Update ~ September 2005
This
research study is no longer active but the data were presented in
the following papers:
Kelly
DP, Mendelsohn NJ , Sobel BE, Bergmann SR: Detection and assessment
by positron emission tomography of a genetically determined defect
in myocardial fatty acid utilization (long-chain acyl-CoA dehydrogenase
deficiency). Am. J. Cardiol. 1993;71:738-744.
Bergmann
SR, Herrero P, Sciacca RR, Hartman JJ, Rubin PJ, Hickey KT, Epstein
S, Kelly DP: Characterization of altered myocardial fatty acid metabolism
in patients with inherited cardiomyopathy. J. Inherit. Metabol.
Dis. 2001;24:657-674.
Steven R. Bergmann, M.D., Ph.D.
Chief, Division of Cardiology
Beth Israel Medical Center
First Avenue at 16th St.
New York, NY 10003
Phone: 212/420-4681
Fax: 212/420-4222
sbergmann@bethisraelny.org
April 13,
2000
The Division of Cardiology in collaboration with the Division
of Pediatric Cardiology of the College of Physicians and Surgeons
of Columbia University at the Columbia-Presbyterian Medical Center
in New York is recruiting patients for a federally funded study
of heart blood flow and fatty acid metabolism using positron emission
tomography (PET) scanning in patients with inherited or acquired
cardiomyopathy (heart failure).
The aim of
the study is to determine the prevalence and severity of abnormal
fatty acid metabolism in patients with inherited or acquired heart
failure in order to gain a better understanding of how heart metabolism
is affected by these disorders. Our ultimate goal is to identify
and treat such cardiomyopathies with pharmacologic therapy designed
to correct metabolic abnormalities, and ultimately, in those with
inherited defects, with gene replacement therapy.
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